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    • 专利摘要:
    The present invention relates to a feed or drinking water composition for poultry comprising a stable bioavailable silicon complex formed between silicic acid having free hydroxyl groups and at least one stabilizing agent based on phenol or polyphenol; said poultry feed or drinking water composition for improving bone strength, and a method of raising poultry by feeding said poultry with a feed or drinking water composition comprising a stable bioavailable silicon complex formed between silicic acid having free hydroxyl groups and at least one stabilizing agent based on phenol or polyphenol.
    公开号:BE1027018B1
    申请号:E20205032
    申请日:2020-01-16
    公开日:2021-01-15
    发明作者:Karine CROIZET-BERGER；Ivan Coste-Maniere
    申请人:Silinnov Scrl；
    IPC主号:
    专利说明:

    COMPOSITION OF FEED AND DRINKWATER FOR POULTRY INCLUDING A STABLE BIODISPONI BLE SILICON COMPLEX
    TECHNICAL FIELD The present invention relates to a poultry feed and drinking water composition, and methods of rearing poultry by dispensing liquid compositions and compounds for such uses.
    More specifically, the present invention relates to the field of compounds and compositions for improving the growth profile of poultry on breeding farms, as well as improving bone strength in poultry.
    INTRODUCTION Poultry farming is the process of keeping domestic birds such as chickens, ducks, turkeys and geese for the purpose of producing meat or eggs for food. Poultry - mainly chickens - are kept in large numbers. Chicken farmers raise more than 50 billion chickens each year as a source of food, both for their meat and for their eggs. Chickens reared for their eggs are generally referred to as laying hens while chickens reared for meat are often referred to as broilers.
    Broilers, commonly known as broilers, are raised on the floor on litter such as wood chips, peanut shells and rice husks, indoors in air-conditioned buildings. In modern husbandry methods, indoor broilers reach slaughter weight between 5 and 9 weeks of age, being selectively bred for this. A broiler chicken, in its first week of life, can grow up to 300 percent of its size.
    A nine week old broiler chicken averages over 9 pounds in body weight.
    Broilers are kept in large, open structures called feeder buildings. A breeder receives the birds from the hatchery when they are only one day old. A fattening takes 5 to 9 weeks depending on the size the chickens need to be for the slaughter plant. These buildings are equipped with mechanical systems to distribute food and water to the birds. The diet of chickens consists mainly of corn and soybean meal with the addition of essential vitamins and minerals. No hormones or steroids are allowed in chicken breeding. Two kilograms of grain must be fed to poultry to produce 1 kg of weight gain, which is far less than what is required for pork or beef. Since dry bedding helps maintain herd health, most feed houses have closed watering systems ("nipple drinkers") that reduce spills.
    The efficiency of rearing poultry, especially chickens, is of utmost importance, and is achieved primarily through the delivery of essential vitamins and minerals. EP 1 176 875 relates to the use of creatine or creatine salts as a fat substitute to be given to breeding and fattening animals. Creatine or creatine salts are used as a substitute for meat meals, fish meal and / or antimicrobial performance enhancers, growth hormones as well as anabolic agents. Document EP0103206 relates to an animal feed composition containing a derivative of dithia. It has been clarified that, by adding the dithia derivative to a feed and administering the feed composition to cattle, poultry, fish, etc., the deposition of fat, in particular abdominal fat, can be reduced without reduction in total body weight, i.e. carcass efficiency can be improved, and in addition, in poultry such as chicken or quail, the strength of the eggshell can be increased.
    WO 2005/120246 relates to the use of guanidino acetic acid and / or salts thereof as a feed additive for animals, in which, in mainly vegetarian diets, salts with acid hydrochloric acid, hydrobromic acid and phosphoric acid are particularly used. Their use is carried out, in particular, in individual doses of 0.01 to 100 g / kg of feed in the form of powder, granules, lozenges or capsules, and the feed additive for animals can also be taken with other substances of physiologically active value. EPO 125 322 describes a process for the use of combinations of ergotropic agents in the rearing and fattening of poultry, pigs and cattle, where 6-methyluracil and N-guanidino-N'-thiouréido -p-Benzoquinone-diimide are used as agents, the combinations of said two agents containing each individual agent in amounts of 2 to 100 ppm in the food, the total amount of the two agents not exceeding 125 ppm. EP 0 585 514 describes an animal feed and additive thereto or drinking water containing an antibiotic combination of 1 part by weight of gentamicin and 5 to 60 parts by weight of lincomycin or clindamycin, from preferably in the form of their pharmacologically acceptable acid addition salts, for the prophylaxis and treatment of infections and hence increasing body weight gain in fattening animals. For increasing body weight gain in poultry, the combination of gentamicin sulfate and lincomycin hydrochloride is very effective. WO 96/08977 describes an agent for increasing the production of / in breeding animals and production animals in the poultry industry, which agent consists of at least one type of xanthophylls. The preferred xanthophyll is astaxanthin. Further, a method for increasing the production of / in breeding and production animals in the poultry industry by administering an agent which consists of at least one type of xanthophylls, preferably astaxanthin, in animal feed, is disclosed. Further, the use of the agent, preferably astaxanthin, for increasing the production of / in breeding and production animals in the poultry industry by administering said agent in feed to said animals is described. .
    The present invention aims to provide novel methods and compositions for raising poultry, which methods and compositions are aimed at improved health and growth profile, as determined by the improved weight profile.
    SUMMARY OF THE INVENTION The present invention provides a solution to at least one of the above problems by providing a poultry feed and drinking water composition comprising a stable bioavailable silicon complex.
    In a first aspect, the present invention provides a feed or drinking water composition for poultry comprising a stable bioavailable silicon complex formed between silicic acid having free hydroxyl groups and at least one stabilizing agent based on phenol or polyphenol, stabilizing at least part of said free hydroxyl groups of silicic acid. The inventors have surprisingly discovered that the distribution of said silicon complex induces an improved growth profile in treated poultry.
    In a second aspect, the present invention provides a poultry feed or drinking water composition according to the first aspect of the invention, for medical use, preferably for improving bone strength in poultry.
    The inventors surprisingly discovered that, in addition to improving weight gain, the treated poultry population exhibited improved bone strength.
    In a third aspect, the present invention provides a process for raising poultry by delivering to said poultry a feed or drinking water composition comprising a stable bioavailable silicon complex formed between silicic acid having free hydroxyl groups. and at least one stabilizing agent based on phenol or polyphenol, stabilizing at least a part of said free hydroxyl groups of silicic acid.
    The inventors have surprisingly discovered that the distribution of said silicon complex induces an improved growth profile in poultry - treated.
    This is observed by means of improved weight gain per day.
    In a fourth aspect, the present invention relates to the use of a stable bioavailable silicon complex formed between silicic acid having free hydroxyl groups and at least one stabilizing agent based on phenol or polyphenol for breeding. poultry.
    DETAILED DESCRIPTION OF THE INVENTION Unless otherwise indicated, all terms used in the disclosure of the invention, including technical and scientific terms, have the meaning as commonly understood by those skilled in the art to which this invention belongs.
    As a further aid, definitions of terms are included in order to better understand the teaching of the present invention.
    As used herein, the following terms have the following meanings: The terms "a", "a" and "the" and "the" as used herein denote both singular and plural, unless the context clearly indicates otherwise.
    By way of example, “a compartment” designates one or more compartments.
    The term "about", as used herein with reference to a measurable value, such as a parameter, quantity, time duration, etc., is intended to encompass variations of +/- 20% or less, preferably +/- 10% or less, more preferably +/- 5% or less, still more preferably +/- 1% or less, and still more preferably +/- 0.1% or less, from and from the specified value, insofar as such variations are appropriate to occur in the invention disclosed. However, it should be understood that the value to which the modifier "about" refers is itself also specifically described.
    The terms "include", "comprising" and "includes" and "consisting of", as used herein, are synonymous with "include", "including", "includes" or " contain "," containing "," contains "and are inclusive or open-ended terms which specify the presence of the following, for example a component, and do not exclude or prevent the presence of components, characteristics, elements , components and additional steps not cited, known in the art or described therein. Reciting number ranges by end points includes all numbers and fractions included in that range, as well as recited end points. All percentages are to be understood as percent by weight and are abbreviated as "% by weight" unless otherwise specified or unless a different meaning is apparent to those skilled in the art from its use and in the art. context where it is used.
    The terms "additional therapeutically active compound" or "additional therapeutic agent", as used in the context of this specification, refer to the use or administration of a compound for additional therapeutic use for a particular injury, illness or disorder being treated. Such a compound, for example, could include a compound used to treat an unrelated disease or disorder. As used herein, the terms "administering" and / or "administering" a compound are understood to mean providing a compound of the disclosure or a prodrug of a compound of the disclosure to a subject in need of treatment.
    The term "antimicrobial agents" as used herein refers to any compound or composition of natural, synthetic, or semi-synthetic or mixture thereof, which is safe for human use or animal, as practiced in the methods described herein, and is effective in killing or substantially inhibiting the growth of microbes. The term "antimicrobial" as used herein includes antibacterial, antifungal, antiviral agents. The term "silicic acid" is to be understood as the generic name for a family of chemical compounds containing the element silicon attached to the oxide and hydroxyl groups. This family of compounds has the general formula [SiOx (OH} 4-2x] n. Examples include metasilicic acid (H2SiOs), i.e. chain or cyclic [SIO (OH) 2] n , orthosilicic acid (H4SiO4, i.e. Si (OH) 4 with pKa: = 9.84, pKa = 13.2 calculated at 25 ° C), disilicic acid (H2Si20s), it is ie the [SiO +, 5 (OH)] n polymer, and pyrosilicic acid (HsSizO7), ie O (Si (OH) s)>. Preferably, said silicic acid is orthosilicic acid The inventors have found that, within the scope of the present invention, orthosilicic acid provides the best performance in medical uses. The term "improving" as used herein refers to the ability of a compound. , an agent, or method for improving a condition, i.e., poultry weight or bone strength, depending on the context in which the term "improving" is used. Preferably, the improvement is at least 1%, more preferably at least 2%, still more pr Preferably at least 5%, and most preferably, the condition is improved by at least 10%.
    As used herein, the term "additional ingredients" includes one or more of: excipients; surfactants; dispersing agents; inert diluents; granulating and disintegrating agents; liaison officers; lubricating agents; sweetening agents; flavoring agents; coloring agents; preservatives; physiologically degradable compositions such as gelatin; aqueous vehicles and solvents; oily vehicles and solvents; suspending agents; dispersing or wetting agents; emulsifying agents, softeners; tampons; salts; thickening agents; charges; emulsifying agents; antioxidants; antibiotics; antifungal agents; agents = stabilizers; and pharmaceutically acceptable polymeric or hydrophobic materials. Other "additional ingredients" which may be included in pharmaceutical compositions are known in the art and described, for example in Genaro, ed. (1985, Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa.).
    Other components such as preservatives, antioxidants, surfactants, absorption activators, viscosity enhancers or film-forming polymers, blowing agents, diluents, flavoring agents, pH modifiers, sweeteners or taste masking agents can also be incorporated into the composition. Suitable flavoring agents include mint, raspberry, licorice, orange, lemon, grapefruit, caramel, vanilla, cherry and grape flavors and combinations thereof. Suitable pH modifiers include, but are not limited to, citric acid, tartaric acid, phosphorous acid, hydrochloric acid, maleic acid and sodium hydroxide. Suitable sweeteners include, but are not limited to Vaspartame, acesulfame K and thaumatin. Suitable taste masking agents include, but are not limited to sodium bicarbonate, vanilla, ion exchange resins, cyclodextrin inclusion compounds, and adsorbates.
    Poultry feed or drinking water composition In a first aspect, the present invention provides a poultry feed or drinking water composition comprising a stable bioavailable silicon complex formed between silicic acid comprising free hydroxyl groups and at least one stabilizing agent based on phenol or polyphenol, stabilizing at least part of said free hydroxyl groups of silicic acid. Without being bound by any mechanistic study, it is assumed that said silicic acid is stabilized by hydrogen bonding and possibly other interactions. The inventors have surprisingly discovered that the distribution of said silicon complex induces an improved growth profile in treated poultry. This is seen through improved weight gain per day. This means that chickens, for example, reach higher target weights for slaughter. In addition, this means that chickens, for example, reach the expected weight for slaughter much earlier, i.e. after 40 days instead of 50 or even 60 days. In addition, it has been found that the weight gain of the poultry progressed much more rapidly compared to the poultry which were not fed with the silicon complex composition of the invention.
    In a preferred embodiment, the present invention relates to a poultry drinking water composition according to the first aspect of the invention. Drinking water is preferred since a concentrated solution of the silicon complex can easily be added to a drinking water supply. The complex is easily and homogeneously mixed in an aqueous liquid solution at the desired concentration, as described below. In a preferred embodiment, the present invention relates to a poultry feed or drinking water composition according to the first aspect of the invention, wherein said composition comprises silicon in an amount of at least 10 µg. per kg of composition as determined by ICP-AES, preferably at least 20 ug per kg, at least 30 ug per kg, at least 40 ug per kg, at least 50 ug per kg, at least 60 µg per kg, at least 70 µg per kg, at least 80 µg per kg, at least 90 µg per kg, or even at least 100 µg per kg. This minimum amount gave the preferred growth enhancement in poultry. Preferably, said composition comprises silicon in an amount of at most 1,000,000 µg per kg of composition, preferably of at most 1,000,000 µg per kg, of at most 900,000 µg per kg, of at most more than 800,000 ug per kg, not more than 700,000 ug per kg, not more than 600,000 ug per kg, not more than 500,000 ug per kg, not more than 400,000 ug per kg, not more than plus 300,000 µg per kg, not more than 200,000 µg per kg, or even not more than 100,000 µg per kg of composition. Higher concentrations do not make it possible to obtain further improved weight growth profiles, thus resulting in a lower efficiency of the silicon complex consumed.
    In a preferred embodiment, the present invention relates to a poultry feed or drinking water composition according to the first aspect of the invention, wherein said composition comprises silicon in an amount of 100 µg per kg of composition at 100,000 µg per kg of composition, as determined by ICP-AES. Preferably, said composition comprises silicon in an amount of at least 100 µg per kg of composition, at least 125 µg per kg, at least 150 µg per kg, at least 200 µg per kg, d at least 250 µg per kg, at least 300 µg per kg, at least 350 µg per kg, at least 400 µg per kg, or even at least 500 µg per kg. Preferably, said composition comprises silicon in an amount of at most 100,000 µg per kg of composition, preferably at most 100,000 µg per kg, at most 90,000 µg per kg, at most 80 000 ug per kg, not more than 70,000 ug per kg, not more than 60,000 ug per kg, not more than 50,000 ug per kg, not more than 40
    000 ug per kg, not more than 30,000 ug per kg, not more than 20,000 ug per kg, not more than 10,000 ug per kg, not more than 50,000 ug per kg of composition.
    In a preferred embodiment, the present invention relates to a poultry feed or drinking water composition according to the first aspect of the invention, wherein said composition comprises silicon in an amount of 500 µg per kg of composition at 2,500 µg per kg of composition, as determined by ICP-AES.
    Preferred concentrations are 500 ug per kg of composition, 600 ug per kg of composition, 700 ug per kg of composition, 800 ug per kg of composition, 900 ug per kg of composition, 1000 ug per kg of composition, 1,100 ug per kg of composition, 1,200 ug per kg of composition, 1,300 ug per kg of composition, 1,400 ug per kg of composition, 1,500 ug per kg of composition, 1,600 ug per kg of composition, 1,700 ug per kg of composition, 1800 ug per kg of composition, 1900 ug per kg of composition, 2000 ug per kg of composition, 2100% g per kg of composition, 2200 ug per kg of composition, 2300 ug per kg of composition, 2400 µg per kg of composition or 2500 µg per kg of composition, or any intermediate concentration.
    In a preferred embodiment, the present invention relates to a poultry feed or drinking water composition according to the first aspect of the invention, wherein the silicic acid is orthosilicic acid having four free hydroxyl groups. .
    The inventors have found that orthosilicic acid provides better results.
    In this complex, orthosilicic acid contains four free hydroxyl groups, which excludes any presence of an organic radical, and consequently of organosilanes.
    Orthosilicic acid is complexed with at least one phenolic or polyphenolic compound, comprising at least one aromatic ring and one or more hydroxyl groups.
    Preferably, it may further contain one or more carbonyl groups (C = O). The aromatic, and therefore sterically hindered, structure of phenolic or polyphenolic compounds and the presence of hydroxyl and possibly carbonyl groups play a fundamental role in the stabilization process.
    Hydrogen bonds characteristic of weak electrostatic bonds are established between the hydroxyl groups of orthosilicic acid and the hydroxyl and carbonyl groups of phenolic compounds.
    Although not bound by any mechanistic theory, it is believed that the esterification reaction between orthosilicic acid and the phenolic (polyphenolic) compound is excluded.
    These bonds prevent the polymerization of orthosilicic acid and the formation of Si-O-Si bonds.
    In a preferred embodiment, the present invention relates to a poultry feed or drinking water composition according to the first aspect of the invention, wherein said stabilizing agent is selected from the group consisting of phenolic acids, phenols, aldehyde derivatives of phenolic acids, cinnamic aldehydes, coumarins, naphthoquinones, flavonoids, stilbenes and mixtures of one or more of the above, preferably wherein said stabilizing agent is 4-hydroxy -3- methoxybenzaldehyde.
    The stabilizer is preferably a phenolic or polyphenolic compound and the following compounds, without limitation, can be exemplified: phenolic acids, such as 3-4-5-trinydroxybenzoic acid, 4-hydroxy-3; methoxybenzoic acid, 3-4-dihydroxybenzoic acid, 4-hydroxy-3,5-dimethoxybenzoic acid, 2-hydroxybenzoic acid, 2-5-dihydroxybenzoic acid, 3- (4 -hydroxyphenyl}, 2-propenoic acid, 3- (3,4-dihydroxyphenyl) prop-2-enoic acid, 3- (4-hydroxy-3-methoxyphenyl) prop-2-enoic acid, l 3- (4-hydroxy-3,5- - dimethoxypheny!) - prop-2-enoic acid, (R) -a - [[3- (3,4-dihydroxyphenyl) -1-oxo- 2E -propenyl] -oxy] -3,4-dihydroxybenzenepropionic, etc .; simple phenols, such as benzene-1,2-diol, benzene-1,3-diol, 2-isopropyl-5-methylphenol; phenylbutanone, such as 1- (4-hydroxyphenyl} -3-butanone; aldehyde derivatives of phenolic acids, such as 4-hydroxy-3-methoxybenzaldehyde, etc .; cinnamic aldehydes, such as 4-allyl- 2-methoxyphenol, 2-methoxy-4-propenylphenol, etc .; coumarins, such as 7-hydroxychromen-2-one, 6,7-dihydroxychromen-2-0ne, etc .; naphthoguinones, such as 5-hydroxy-1,4-naphthoquinone, and vs.; flavonoids, such as catechin (2- (3,4-dihydroxyphenyl) chromane-3,5,7-triol) and epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) , epigallocatechin gallate (EGCG), kaempferol, quercetol, luteolin, etc .; stilbenes such as resveratrol, pinosylvine, piceatannol, pterostilbene, etc.
    Preferred stabilizers are 4-hydroxy-3-methoxybenzaldehyde, 1- (4-hydroxyphenyl) -3-butanone, 2-hydroxybenzoic acid, and (2- (3,4 -dihydroxyphenyl) -chromane-3, 5,7-triol). In a more preferred embodiment, the present invention provides a composition according to the first aspect of the invention, wherein said stabilizing agent is 4-hydroxy-3-methoxybenzaldehyde.
    In a preferred embodiment, the present invention relates to a poultry feed or drinking water composition according to the first aspect of the invention, further comprising one or more therapeutic agents, preferably selected from the group consisting of by vitamins, antimicrobial agents, disinfectants, fungicides, anti-inflammatories, plant extracts, antibacterial agents, antifungals, antivirals, and antibiotics.
    Poultry feed or drinking water compositions for medical use
    In a second aspect, the present invention provides a poultry feed or drinking water composition according to the first aspect of the invention, for medical use, preferably for improving bone strength in poultry.
    The inventors surprisingly discovered that, in addition to improving weight gain, the treated poultry population exhibited improved bone strength.
    This is advantageous to avoid breaking the legs due to the increased weight.
    In a preferred embodiment, the present invention relates to a poultry feed or drinking water composition according to the second aspect of the invention, wherein said poultry is chicken.
    Preferably, said chicken is aged between 1 and 60 days, preferably between 1 and 40 days.
    Favorite compositions
    In a preferred embodiment, the present invention relates to a composition according to the first or second aspect of the invention, wherein said composition is a drinking water composition and wherein said composition has a pH of less than 6, preferably less than 4, and equal to or greater than 2, preferably between 2.5 and 3.5, and an Si content of between 300 ppm and 1400 ppm by weight per volume of the composition and a ratio between Si content (% p./vol. of said composition) and the stabilizing agent content (% w./vol. of said composition) of between 0.1 and 1. Preferably, said composition has an Si content of between 0.4 ppm and 1.2 ppm by weight per volume of preparation, plus
    - preferably between 0.5 ppm and 1.1 ppm by weight per volume of preparation, even more preferably between 0.6 ppm and 1.0 ppm by weight per volume of preparation, and most preferably between 0, 7 ppm and 0.9 ppm by weight per volume of preparation.
    The Si content of the preparation and the% Si (p./vol.)-% ratio of stabilizer (p./vol.) Indicated above must be observed for the preparation to contain sufficient silicon complex bioavailable and without risk of polycondensation.
    More preferably, the ratio of Si (p./vol.)-% stabilizing agent (p./vol.) Is between 0.5 and 0.9, in particular between 0.6 and 0.8. In a preferred embodiment, the present invention relates to a composition according to the first or second aspect of the invention, further comprising one or more therapeutic agents.
    Preferably, said additional therapeutic agent is chosen from the group consisting of vitamins, antimicrobial agents, disinfectants, fungicides, anti-inflammatories, wound care products, wound healing agents, plant extracts, animal extracts, cell extracts, antibacterial agents, antifungal agents, antiviral agents, and antibiotics.
    Several preferred embodiments include the use of any therapeutic molecule, including any pharmaceutical or drug.
    Examples of pharmaceuticals include sedatives and sleep inducers, antiallergics, anti-arthritics, appetite suppressants, muscle relaxants, vitamins, antimicrobial agents, antacids, antiseptics, diuretics, disinfectants, fungicides, ectoparasiticides, antiparasites, antioxidants, vitamins, cosmetics, anti-inflammatories, wound care products, wound-healing agents, plant extracts, emollients, antibacterial agents, antifungals, antivirals, and antibiotics.
    A list of types of drugs, and specific drugs within the categories that are included in the invention, is provided below and is intended to provide non-limiting examples.
    Antimicrobial agents include: silver sulfadiazine, nystatin, nystatin / triamcinolone, bacitracin, nitrofurazone, nitrofurantoin, polymyxin (eg, colistin, surfactin, polymixin E, and polymyxin B), doxycycline, antimicrobial peptides (eg, naturally occurring and synthetic), neosporin (eg, bacitracin, polymyxin B, and neomycin), polysporin (ie, bacitracin and polymyxin B). Additional antimicrobials include topical antimicrobials (i.e., antiseptics), examples of which include silver salts, iodine, benzalkonium chloride, alcohol, hydrogen peroxide, and chlorhexidine.
    Anti-inflammatory: aceclofenac; alclometasone dipropionate; algestone acetonide; alpha amylase; amcinafal; amcinafide; sodium of amfenac; Amiprilose hydrochloride; anakinra; anirolac; anitrazafen; apazone; disodium balsalazide; bendazac; benoxaprofen; benzydamine hydrochloride; bromelain; broperamole; budesonide; carprofen; cicloprofen; cintazone; cliprofen; clobetasol propionate; clobetasone butyrate; clopirac; cloticasone propionate; cormethasone acetate; cortodoxone; deflazacort; desonide; deoximetasone; dexamethasone dipropionate; diclofenac potassium; diclofenac sodium; diflorasone diacetate; diflumidone sodium; diflunisal; difluprednate; diftalone;
    dimethylsulfoxide; drocinonide; endrysone; enlimomab; enolicam sodium; epirizole; etodolac; etofenamate; felbinac; fenamole; fenbufen; fenclofenac; fenclorac; fendosal; fenpipalone; fentiazac; flazalone; fluazacort; flufenamic acid; flumizole; flunisolide acetate; flunixin; flunixin meglumine; fluocortin butyl; fluorometholone acetate; fluquazone; flurbiprofen;
    fluretofen; fluticasone propionate; furaprofen; furobufen; halcinonide; halobetasol propionate; halopredone acetate; ibufenac; ibuprofen ; ibuprofen aluminum; ibpuprofen piconol; ilonidap; indomethacin; indomethacin sodium; indoprofen; indoxole; intrazole; isoflupredone acetate; isoxepac; isoxicam; ketoprofen; lofemizole hydrochloride; lornoxicam; loteprednol etabonate;
    sodium meclofenamate; meclofenamic acid; Meclorisone dibutyrate; mefenamic acid; mesalamine; meseclazone; methylprednisolone suleptanate; momiflumate; nabumetone; naproxen; naproxen sodium; naproxol; nimazone; olsalazine sodium; orgoteine; orpanoxin; oxaprozin; oxyphenbutazone; paranyline hydrochloride; sodium pentosan polysulfate;
    sodium phenylbutazone glycerate; pirfenidone; piroxicam; piroxicam cinnamate; piroxicam olamine; pirprofen; prednazate; prifelone; prodolic acid; proquazone; proxazole; proxazole citrate; rimexolone; romazarit; salcolex; salnacedin; salsalate; sanguinarium chloride; seclazone; sermetacin; sudoxicam; sulindac; suprofen; talmetacin; talniflumate; talosalate; tebufelone; tenidap; tenidap sodium; tenoxicam; tesicam; tesimide; tetrydamine; tiopinac; tixocortol pivalate; tolmetin; tolmetin sodium; triclonide; triflumidate; zidomethacin; zomepirac sodium.
    Suitable solvents for the composition according to the first or the second aspect of the invention can be chosen from water, aliphatic and aromatic alcohols, sulfoxides, fatty acids, fatty acid esters, polyols, amides. , surfactants, terpenes, alkanones, organic acids and mixtures thereof.
    Suitable alcohols include, without limitation, ethanol, propanol, butanol, pentanol, hexanol, octanol, nonanol, decanol, 2-butanol, 2-pentanol, benzyl alcohol, phenoxyethanol, capryl alcohol, decyl alcohol, lauryl alcohol, 2-lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, alcohol linolyl, linolenic alcohol and mixtures thereof.
    Volatile aliphatic alcohols having 2 to about 8 carbon atoms, preferably 2 to about 5 carbon atoms, can provide a dual function, serving as both a volatile carrier and a penetration enhancer.
    Aromatic alcohols, such as benzyl alcohol, phenoxyethanol, and the like can provide a dual function, serving as both a substantially non-volatile permeation enhancer and an auxiliary anti-infective.
    The preferred alcohols are ethanol and benzyl alcohol.
    Suitable sulfoxides include dimethylsulfoxide, decylmethylsulfoxide, and mixtures thereof.
    Suitable fatty acids include valeric, heptanoic, pelargonic, caproic,
    capric, lauric, myristic, stearic, oleic, linoleic, linolenic, caprylic, isovaleric, neopentanoic, neoheptanoid, neononanoic, trimethyl hexanoic, neodecanoic and isostearic, and mixtures thereof.
    Suitable fatty acid esters include isopropyl n-butyrate, isopropyl n-hexanoate, isopropyl n-decanoate, isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, ethyl acetate, butyl acetate, methyl acetate, methylvalerate, methylpropionate, diethyl sebacate, ethyl oleate, ethyl laurate and mixtures thereof.
    Suitable polyols include propylene glycol, polyethylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, dipropylene glycol, glycerol, propanediol, sorbitol, dextran, butanediol, pentanediol, hexanetriol , and their mixtures.
    Suitable amides include urea, dimethylacetamide, diethyltoluamide, dimethylformamide, dimethyloctamide, dimethyldecamide, pyrrolidone derivatives, 1-alkyl-4-imidazoline-2-0ne, cyclic amides, hexamethylenelauramide and its derivatives. , diethanolamine, triethanolamine and their mixtures.
    Suitable pyrrolidone derivatives include 1-methyl-2-pyrrolidone, 2-pyrrolidone, 1-lauryl-2-pyrrolidone, 1-lauryl-4-carboxy-2-pyrrolidone, 1-methyl-4- carboxy-2-pyrrolidone, 1-hexyl-4-carboxy-2-pyrrolidone, 1-decylthioethyl-2-pyrrolidone, N-cyclohexyl-pyrrolidone, 1-methyl-4-methoxycarbonyl-2-pyrrolidone, 1 -hexyl-4-methoxycarbonyl-2-pyrrolidone, 1-lauryl-4-methoxycarbonyl-2-pyrrolidone, N-dimethylamino-propyl-pyrrolidone, N-cocoylpyrrolidone, N-tallowylpyrrolidone, fatty acid esters of N- (2-hydroxymethyl) -2-pyrrolidone, and mixtures thereof.
    Suitable cyclic amides include 1-dodecylazacycloheptan-2-one, 1-geranylazacycloheptan-2-one, 1-farnesylazacycloheptan-2-0ne, 1-geranyl-geranyl-azacycloheptan-2-one, 1- (3 , 7-dimethyloctyl) azacycloheptan-2-0ne, 1- (3,7,11-trimethyl-octyl) azacycloheptan-2-one, 1-geranylazacyclohexan-2-one, la
    1-geranyl-azacyclopentan-2,5-dione, 1-farnesylazacyclopentan-2-one, and mixtures thereof.
    Suitable surfactants include anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants, and lecithin. Suitable anionic surfactants include sodium laurate, sodium lauryl sulfate, and mixtures thereof. Suitable cationic surfactants include cetyltrimethylammonium bromide, tetradecyltrimethylammonium bromide, benzalkonium chloride, octadecyltrimethylammonium chloride, cetylpyridinium chloride, dodecyltrimethylammonium chloride, hexadecyltrimethylammonium chloride, and mixtures thereof. Suitable nonionic surfactants include alpha-hydro- (D-hydroxy poly (oxyethylene) -poly (oxypropyl) poly (oxyethylene) block copolymers, polyoxyethylene ethers, polyoxyethylene sorbitan esters, polyethylene glycol esters. and fatty alcohols, and mixtures thereof. Suitable alpha-hydro-co-hydroxy-poly (oxyethylene) -poly (oxypropyl) poly (oxyethylene) block copolymers include poloxamers 182, 184, 231, and mixtures thereof. Polyethylene glycol suitable fatty acids include polyoxyethylene, polyoxyethylene monostearate, polyoxyethylene monostearate, and mixtures thereof. Suitable amphoteric surfactants include, but are not limited to, lauramidopropyl betaine, cocamidopropy! betaine, lauryl betaine, cocobetaine, cocamidopropyl-hydroxy-sultaine, aminopropyl laurylglutamide, sodium cocoamphoacetate, sodium lauroamphoacetate, disodium lauroamphodiacetate, coc disodium oamphodiacetate, sodium cocoamphopropionate, disodium lauroamphodipropionate, disodiumcocoampho-dipropionate, sodium lauriminodipropionate, disodiumcocoampho-carboxy-methylhydroxy-propylsulfate, and the like. Suitable terpenes include D-limonene, α-pinene, B-enene, terpineol, terpinene-4-ol, carvol, carvone, pulegone, piperitone, menthone, menthol , geraniol, cyclohexene oxide, limonene oxide, α-pinne oxide, cyclopentene oxide, 1,8-cineol, ylang-ylang oil, gasoline anise, lamb's quarters oil, eucalyptus oil, and mixtures thereof. Suitable alkanones include N-heptane, N-octane, N-nonane, N-decane, N-undecane, N-dodecane, N-tridecane, N-tetradecane, N-hexadecane, and their mixtures. Suitable organic acids include citric acid, succinic acid, salicylic acid, salicylates (including methyl, ethyl and propyl glycol derivatives), tartaric acid, and mixtures thereof.
    Method of Rearing Poultry In a third aspect, the present invention provides a method of rearing poultry by delivering to said poultry a feed or drinking water composition comprising a stable bioavailable silicon complex formed between the acid. silicic acid comprising free hydroxyl groups and at least one stabilizing agent based on phenol or polyphenol, stabilizing at least part of said free hydroxyl groups of silicic acid. Without being bound by any mechanistic study, it is assumed that said silicic acid is stabilized by hydrogen bonding and possibly other interactions. The inventors have surprisingly discovered that the distribution of said silicon complex induces an improved growth profile in treated poultry.
    This is seen through improved weight gain per day. This means that chickens, for example, reach higher target weights for slaughter. In addition, it means that chickens, for example, reach the expected slaughter weight much sooner, i.e. after 40 days instead of 50 or even 60 days. In addition, it has been found that the weight gain of the poultry progressed much more rapidly compared to the poultry which were not fed with the silicon complex composition of the invention. In a preferred embodiment, the present invention relates to a method according to the third aspect of the invention, wherein said silicon complex is included in drinking water. Drinking water is preferred since a concentrated solution of the silicon complex can easily be added to a drinking water supply. The complex is easily and homogeneously mixed in an aqueous liquid solution at the desired concentration, as described below.
    In a preferred embodiment, the present invention relates to a method according to the third aspect of the invention, wherein said composition comprises silicon in an amount of at least 10 µg per kg of composition, as determined by the ICP-AES, preferably at least 20 ug per kg, at least 30 ug per kg, at least 40 ug per kg, at least 50 ug per kg, at least 60 ug per kg , at least 70 µg per kg, at least 80 µg per kg, at least 90 µg per kg, or even at least 100 µg per kg. These minimal amounts give the preferred growth enhancement in poultry. Preferably, said composition comprises silicon in an amount of at most 1,000,000 µg per kg of composition, preferably of at most 1,000,000 µg per kg, of at most 900,000 µg per kg, of at most more than 800,000 ug per kg, not more than 700,000 ug per kg, not more than 600,000 ug per kg, not more than 500,000 ug per kg, not more than 400,000 ug per kg, not more than plus 300,000 µg per kg, not more than 200,000 µg per kg, or even not more than 100,000 µg per kg of composition. Higher concentrations do not allow to obtain further improved weight growth profiles, thus resulting in a lower efficiency of the silicon complex consumed.
    In a preferred embodiment, the present invention relates to a method according to the third aspect of the invention, wherein said composition comprises silicon in an amount from 100 µg per kg of composition to 100,000 µg per kg of composition, such as as determined by VICP-AES. Preferably, said composition - comprises silicon in an amount of at least 100 µg per kg of composition, at least 125 µg per kg, at least 150 µg per kg, at least 200 µg per kg, at least 250 µg per kg, at least 300 µg per kg, at least 350 µg per kg, at least 400 µg per kg, or even at least 500 µg per kg. Preferably, said composition comprises silicon in an amount of at most 100,000 µg per kg of composition, preferably at most 100,000 µg per kg, at most 90,000 µg per kg, at most 80 000 ug per kg, not more than 70,000 ug per kg, not more than 60,000 ug per kg, not more than 50,000 ug per kg, not more than 40,000 ug per kg, not more than 30 000 µg per kg, at most 20,000 µg per kg, at most 10,000 µg per kg, at most 50,000 µg per kg of composition.
    In a preferred embodiment, the present invention relates to a method according to the third aspect of the invention, wherein said composition comprises silicon in an amount of 500 µg per kg of composition to 2500 µg per kg of composition, such as determined by ICP-AES. Preferred concentrations are 500 ug per kg of composition, 600 ug per kg of composition, 700 ug per kg of composition, 800 ug per kg of composition, 900 ug per kg of composition, 1000 ug per kg of composition, 1,100 ug per kg of composition, 1,200 ug per kg of composition, 1,300 ug per kg of composition, 1,400 ug per kg of composition, 1,500 ug per kg of composition, 1,600 ug per kg of composition, 1,700 ug per kg of composition, 1800 ug per kg of composition, 1900 ug per kg of composition, 2000 ug per kg of composition, 2100 ug per kg of composition, 2200 ug per kg of composition, 2300 ug per kg of composition, 2400 µg per kg of composition or 2500 µg per kg of composition, or any intermediate concentration.
    In a preferred embodiment, the present invention relates to a method according to the third aspect of the invention, wherein said poultry is chicken, and wherein said chicken is aged between 1 and 60 days, preferably between 1 and 40 days.
    In a preferred embodiment, the present invention relates to a method according to the third aspect of the invention, wherein said silicic acid is orthosilicic acid having four free hydroxyl groups.
    In a preferred embodiment, the present invention relates to a process according to the third aspect of the invention, wherein said stabilizing agent is selected from the group consisting of phenolic acids, phenols, aldehyde derivatives of phenolic acids, - cinnamic aldehydes, coumarins, naphthoquinones, flavonoids, stilbenes and mixtures of one or more of the above, preferably in which said stabilizing agent is 4-hydroxy-3-methoxybenzaldehyde.
    In a preferred embodiment, the present invention relates to a method according to the third aspect of the invention, further comprising the step of introducing one or more therapeutic agents, preferably selected from the group consisting of vitamins, antimicrobial agents, disinfectants, fungicides, anti-inflammatories, plant extracts, antibacterial agents, antifungals, antivirals and antibiotics.
    Use In a fourth aspect, the present invention relates to the use of a stable bioavailable silicon complex formed between silicic acid having free hydroxyl groups and at least one stabilizing agent based on phenol or polyphenol for animal husbandry. of poultry.
    EXAMPLES The following examples are intended to further clarify the present invention, and are in no way intended to limit the scope of the present invention.
    EXAMPLE 1. Poultry drinking water comprising a stabilized complex of orthosilicic acid and 4-hydroxy-3-methoxybenzaldehyde (vanillin) Super-pure vanillin with guaranteed purity of 99.9% is used. The “Fine Mesh” or “Free Flow” alternatives will be preferred. 76 g of vanillin powder are dissolved with stirring at 40 ° C. in 100 ml of 40% ethanol. The homogeneous mixture obtained is slowly diluted with demineralized water from osmosis so that the final volume ratio of the solution by volume - of sodium orthosilicate introduced is equal to 225. The pH is then adjusted between 1, 5 and 2.5 with a 14.5 N phosphoric acid solution. Sodium orthosilicate (428 g, density: 1.35) is then added to the mixture, dropwise, with stirring. The solution is kept under constant stirring. When adding sodium orthosilicate, the temperature is maintained within a range of 10 to 15 ° C. The pH is adjusted to between 2.5 and 3.5 with 30% (w / w) phosphoric acid solution, after which the solution is diluted by adding 999 L of water per 1 L of solution. The resulting solution is clear and colorless. It has an Si content of 860 mg / L and a% Si (w / v) /% vanillin (w / v) ratio of 0.8.
    The solution is distributed as a drinking water solution to chickens over a period of day 1 to day 40 in regular feed amounts. The chickens exhibited an improved growth rate with additional growth of about 100 grams of weight per day, compared to a control population of chickens fed without the silicon complex according to the invention.
    As a further beneficial effect, the bone strength of the chickens was significantly enhanced.
    EXAMPLE 2. Drinking water for poultry comprising a stabilized complex of orthosilicic acid and 1- (4-hydroxyphenyl!) - 3-butanone (frambinone) 410 g of frambinone are dissolved with stirring at 40 ° C in 467 g of 40% ethanol. When the solution containing the phenolic compound is clear, it is diluted in an aqueous phase which represents 223 times the volume of the precursor.
    The solution is then acidified using an 85% by weight solution of phosphoric acid to reach a pH between 1.5 and 2.5. 1794 g of potassium metasilicate (density: 1.35) are then added to the mixture, dropwise, with stirring.
    The solution is stirred until complete hydrolysis of the precursor.
    When adding the potassium metasilicate, the temperature is maintained within a range of 10 to 15 ° C.
    The pH is checked and, if necessary, adjusted between 2.5 and 3.5, after which the solution is diluted by adding 999 L of water to 1 L of solution.
    The solution obtained is translucent and colorless.
    It has an Si content of 270 mg / L and a% Si (w / v) /% stabilizer (w / v) ratio of 0.2. The solution is distributed as a drinking water solution to chickens over a period of 1 to 40 days in regular feed amounts.
    The chickens exhibited an improved growth rate with additional growth of more than 50 grams of weight per day, compared to a control population of chickens fed without the silicon complex according to the invention.
    As a further beneficial effect, the bone strength of the chickens was significantly enhanced.
    EXAMPLE 3. Drinking water for poultry comprising a stabilized complex of acid - orthosilicic and 2-hydroxybenzoic acid 1.1 moles of a crystalline powder of 2-hydroxybenzoic acid is dissolved with stirring at 40 ° C. in 200 g. 40% ethanol. After solubilization of the phenolic compound, osmosis water is added slowly, with stirring, so that the ratio of the final volume / volume of precursor introduced is equal to 225. The pH is adjusted between 1.5 and 2.5 with a 14.5 N solution of phosphoric acid. 4.5 moles of potassium orthosilicate are then added to the mixture, dropwise, with stirring.
    The hydrolysis process begins.
    When adding the silicon compound, the temperature is maintained within a range of 10 to 15 ° C.
    The pH is adjusted to between 2.5 and 3.5, after which the solution is diluted by adding 999 L of water to 1 L of solution.
    The solution has an Si content of 660 mg / L and a% Si (w / v) /% stabilizer (w / v) ratio of 0.9. The solution is distributed as a drinking water solution to chickens over a period of day 1 to day 40 in regular feed amounts.
    The chickens exhibited an improved growth rate with additional growth of about 100 grams of weight per day, compared to a control population of chickens fed without the silicon complex according to the invention. As a further beneficial effect, the bone strength of the chickens was significantly enhanced.
    EXAMPLE 4. Poultry drinking water comprising a stabilized complex of orthosilicic acid and (() -2- (3,4-dihydroxyphenyl) chromane-3,5,7-triol) (catechin) 30.83 g of catechin. are dissolved with stirring at 40 ° C. in 288 ml of 40% ethanol. A volume of osmosis water which represents 225 times the volume of the precursor is then slowly added to the solution and the pH is adjusted between 1.5 and 2.5 with a 14.5 N phosphoric acid solution. 56 g of sodium metasilicate are then added to the mixture dropwise, with stirring. When adding the sodium metasilicate, the temperature is kept within a range of 10 to 15 ° C. The pH is checked and, if necessary, adjusted between 2.5 and 3.5, after which the solution is diluted by adding 999 L of water to 1 L of solution. The solution obtained has an Si content of 1370 mg / L and a% Si (w / v) /% stabilizer (w / v) ratio of 0.4.
    The solution is distributed as a drinking water solution to chickens over a period of day 1 to day 40 in regular feed amounts. The chickens exhibited an improved growth rate with additional growth of about 100 grams of weight per day, compared to a control population of chickens fed without the silicon complex according to the invention. As a further beneficial effect, the bone strength of the chickens was significantly enhanced.
    EXAMPLE 5. Drinking water for poultry comprising a stabilized complex of orthosilicic acid and (() -2- (3,4-dihydroxyphenyl) chromane-3,5,7-triol) 30.83 g of catechin are dissolved in stirring at 40 ° C in 288 ml of 40% ethanol. Osmosis water is then slowly added to the solution, so that the ratio of final volume / volume of precursor introduced is equal to 225, after which the pH is adjusted between 1.5 and 2.5 with a solution. of phosphoric acid of 14.5 N. 96 g of tetraethoxysilane (density: 0.93) are then added to the mixture, dropwise, with stirring. When adding the tetraethoxysilane, the temperature is maintained within a range of 15-18 ° C. The pH is checked and, if necessary, adjusted between 2.7 and 3.0: after which the solution is diluted by adding 999 L of water to
    1 L of solution. The solution obtained has an Si content of 550 mg / L and a% Si (w / v) /% stabilizer (w / v) ratio of 0.4. The solution is distributed as a drinking water solution to chickens over a period of day 1 to day 40 in regular feed amounts. The chickens exhibited an improved growth rate with additional growth of about 100 grams of weight per day, compared to a control population of chickens fed without the silicon complex according to the invention. As a further beneficial effect, the bone strength of the chickens was significantly enhanced.
    EXAMPLE 6. Poultry feed comprising a stabilized complex of orthosilicic acid and 4-hydroxy-3-methoxybenzaldehyde (vanillin) Super-pure vanillin with guaranteed purity of 99.9% is used. The “Fine Mesh” or “Free Flow” alternatives will be preferred. 76 g of vanillin powder are dissolved with stirring at 40 ° C. in 100 ml of 40% ethanol. The homogeneous mixture obtained is slowly diluted with demineralized water from osmosis so that the final volume ratio of the solution per volume of sodium orthosilicate introduced is equal to 225. The pH is then adjusted to 1.5. and 2.5 with a 14.5 N phosphoric acid solution. Sodium orthosilicate (428 g, density: 1.35) is then added to the mixture, dropwise, with stirring. The solution is kept under constant stirring. When adding sodium orthosilicate, the temperature is maintained within a range of 10 to 15 ° C. The pH is adjusted to 2.5 to 3.5 with 30% (w / w) phosphoric acid solution. The resulting solution is clear and colorless. It has an Si content of 860 mg / L and a% Si (w / v) /% vanillin (w / v) ratio of 0.8.
    The solution is then sprayed onto 1000 kg of corn and soybean flour and the mixture is homogenized. Poultry feed is fed to chickens over a 1 to 40 day period in regular feed amounts. The chickens exhibited an improved growth rate with additional growth of about 100 grams of weight per day, compared to a control population of chickens fed without the silicon complex according to the invention.
    As a further beneficial effect, the bone strength of the chickens was significantly enhanced.
    EXAMPLE 7. Poultry feed comprising a stabilized complex of orthosilicic acid and 1- (4-hydroxyphenyl!) - 3-butanone (frambinone) 410 g of rambinone are dissolved with stirring at 40 ° C. in 467 g of ethanol at 40 ° C. 40%. When the solution containing the phenolic compound is clear, it is diluted in an aqueous phase which represents 223 times the volume of the precursor.
    The solution is then acidified using an 85% by weight solution of phosphoric acid to reach a pH between 1.5 and 2.5. 1794 g of potassium metasilicate (density: 1.35) are then added to the mixture, dropwise, with stirring.
    The solution is stirred until complete hydrolysis of the precursor.
    When adding the potassium metasilicate, the temperature is maintained within a range of 10 ° C to ° C.
    The pH is checked and, if necessary, adjusted between 2.5 and 3.5. The solution obtained is translucent and colorless.
    It has an Si content of 270 mg / L and a% Si (w / v) /% stabilizer (w / v) ratio of 0.2. The solution is then sprayed onto 1000 kg of corn and soybean flour and the mixture is homogenized.
    Poultry feed is fed to chickens over a 1 to 40 day period in regular feed amounts.
    The chickens exhibited an improved growth rate with additional growth of more than 50 grams of weight per day, compared to a control population of chickens fed without the silicon complex according to the invention.
    As a further beneficial effect, the bone strength of the chickens was significantly enhanced.
    EXAMPLE 8. Feed for poultry comprising a stabilized complex of orthosilicic acid and 2-hydroxybenzoic acid 1.1 moles of a crystalline powder of 2-hydroxybenzoic acid is dissolved with stirring at 40 ° C. in 200 g of ethanol. at 40%. After solubilization of the phenolic compound, osmosis water is added slowly, with stirring, so that the ratio of the final volume / volume of precursor introduced is equal to 225. The pH is adjusted between 1.5 and 2.5 with a 14.5 N solution of phosphoric acid. 4.5 moles of potassium orthosilicate are then added to the mixture, dropwise, with stirring.
    The hydrolysis process begins.
    When adding the silicon compound, the temperature is maintained within a range of 10 to 15 ° C.
    The pH is adjusted between 2.5 and 3.5. The solution has an Si content of 660 mg / L and a% Si (w / v) /% stabilizer (w / v) ratio of 0.9.
    The solution is then sprayed onto 1000 kg of corn and soybean flour and the mixture is homogenized. Poultry feed is fed to chickens over a 1 to 40 day period in regular feed amounts. The chickens exhibited an improved growth rate with additional growth of about 100 grams of weight per day, compared to a control population of chickens fed without the silicon complex according to the invention. As a further beneficial effect, the bone strength of the chickens was significantly enhanced.
    EXAMPLE 9. Feed for poultry comprising a stabilized complex of orthosilicic acid and of (() 2- (3,4-dihydroxyphenyl) chromane-3,5,7-triol) (catechin) 30.83 g of catechin are dissolved in stirring at 40 ° C in 288 ml of 40% ethanol. A volume of osmosis water which represents 225 times the volume of the precursor is then slowly added to the solution and the pH is adjusted between 1.5 and 2.5 with a 14.5 N phosphoric acid solution. 56 g of sodium metasilicate are then added to the mixture dropwise, with stirring. When adding the sodium metasilicate, the temperature is kept within a range of 10 to 15 ° C. The pH is checked and, if necessary, adjusted between 2.5 and 3.5. The solution obtained has an Si content of 1370 mg / L and a% Si (w / v) /% stabilizer (w / v) ratio of 0.4.
    The solution is then sprayed onto 1000 kg of corn and soybean flour and the mixture is homogenized. Poultry feed is fed to chickens over a 1 to 40 day period in regular feed amounts. The chickens exhibited an improved growth rate with additional growth of about 100 grams of weight per day, compared to a control population of chickens fed without the silicon complex according to the invention. As another beneficial effect, the strength of the bones of the chickens was significantly enhanced.
    EXAMPLE 10. Feed for poultry comprising a stabilized complex of orthosilicic acid and (() -2- (3,4-dihydroxyphenyl) chromane-3,5,7-triol) 30.83 g of catechin are dissolved with stirring at 40 ° C in 288 ml of 40% ethanol. Osmosis water is then slowly added to the solution, so that the ratio of final volume / volume of precursor introduced is equal to 225, after which the pH is adjusted between 1.5 and 2.5 with a solution. of phosphoric acid of 14.5 N. 96 g of tetraethoxysilane (density: 0.93) are then added to the mixture, dropwise, with stirring. Upon addition of the tetraethoxysilane, the temperature is maintained within a range of 15-18 ° C. The pH is checked and, if necessary, adjusted between 2.7 and 3.0. The solution obtained has an Si content of 550 mg / L and a% Si (w / v) /% stabilizer (w / v) ratio of 0.4. The solution is then sprayed onto 1000 kg of corn and soybean flour and the mixture is homogenized. Poultry feed is fed to chickens over a 1 to 40 day period in regular feed amounts. The chickens exhibited an improved growth rate with additional growth of about 100 grams of weight per day, compared to a control population of chickens fed without the silicon complex according to the invention. As a further beneficial effect, the bone strength of the chickens was significantly enhanced.
    EXAMPLE 11. Poultry drinking water comprising a stabilized complex of orthosilicic acid and 4-hydroxy-3-methoxybenzaldehyde (vanillin) The solution is distributed to turkeys. The solution of Example 1 is dispensed as a drinking water solution to turkeys over a period of day 1 through day 60 in regular feed amounts. The turkeys exhibited an improved growth rate compared to a control population of turkeys fed without the silicon complex according to the invention.
    EXAMPLE 12. Poultry feed comprising a stabilized complex of orthosilicic acid and 2-hydroxybenzoic acid The solution as obtained in Example 3 is then sprayed onto 1000 kg of corn and soybean flour and the mixture is homogenized. . Poultry feed is fed to turkeys over a 1 to 60 day period in regular feed amounts. The turkeys exhibited an improved growth rate compared to a control population of turkeys fed without the silicon complex according to the invention.
    | It should be understood that the present invention is in no way limited to the embodiments described above and that numerous modifications may be made thereto within the scope of the appended claims.
    Similar results can be expected for other types of poultry, also when different feeding regimes are applied.
    权利要求:
    Claims (15)
    [1]
    1. A composition of poultry feed or drinking water comprising a stable bioavailable silicon complex formed between silicic acid having free hydroxyl groups and at least one stabilizing agent based on phenol or polyphenol.
    [2]
    2. A poultry feed or drinking water composition according to claim 1, wherein said silicon complex is included in drinking water.
    [3]
    A poultry feed or drinking water composition according to claim 1 or 2, wherein said composition comprises silicon in an amount of 100 µg / kg of composition to 100,000 µg / kg of composition, as determined. by ICP-AES.
    [4]
    4. A poultry feed or drinking water composition according to any one of claims 1 to 3, wherein said composition comprises silicon in an amount of 500 µg / kg of composition to 2,500 µg / kg of. composition, as determined by ICP-AES.
    [5]
    5. A poultry feed or drinking water composition according to any one of claims 1 to 4, wherein said silicic acid is orthosilicic acid having four free hydroxyl groups.
    [6]
    6. Composition of feed or drinking water for poultry according to any one of claims 1 to 5, wherein said stabilizing agent is selected from the group comprising phenolic acids, phenols, aldehyde derivatives of phenolic acids. , cinnamic aldehydes, coumarins, ... - naphthoquinones, flavonoids, stilbenes and mixtures of one or more of the above, preferably wherein said stabilizing agent is 4-hydroxy-3-methoxybenzaldehyde.
    [7]
    7. A feed or drinking water composition for poultry according to any one of claims 1 to 6, for improving bone strength in poultry.
    [8]
    8. A poultry feed or drinking water composition according to claim 7, wherein said poultry is chicken and wherein said chicken is between 1 and 60 days old, preferably between 1 and 40 days.
    [9]
    9. A method of rearing poultry by feeding said poultry with a composition of feed or drinking water for poultry comprising a stable bioavailable silicon complex formed between silicic acid having free hydroxyl groups and at least one agent. stabilizer based on phenol or polyphenol.
    [10]
    10. The method of claim 9, wherein said silicon complex is included in drinking water.
    [11]
    A method according to claim 9 or 10, wherein said composition comprises silicon in an amount of 100 µg / kg to 100,000 µg / kg of composition, as determined by ICP-AES, preferably in an amount of. 500 µg / kg to 2500 µg / kg of composition, as determined by ICP-AES.
    [12]
    12. A method according to any one of claims 9 to 11, wherein the poultry is chicken, and wherein said chicken is between 1 and 60 days old, preferably between 1 and 40 days.
    [13]
    13. The method of any one of claims 9 to 12, wherein said silicic acid is orthosilicic acid having four free hydroxyl groups.
    [14]
    14. Method according to any one of claims 9 to 13, wherein said stabilizing agent is chosen from the group comprising phenolic acids, phenols, aldehyde derivatives of phenolic acids, cinnamic aldehydes, coumarins, naphthoquinones, flavonoids, stilbenes and mixtures of one or more of the above, preferably wherein said stabilizing agent is 4-hydroxy-3-methoxybenzaldehyde.
    [15]
    15. Use of a stable bioavailable silicon complex formed between silicic acid having free hydroxyl groups and at least one stabilizing agent based on phenol or polyphenol for poultry farming.
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    同族专利:
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    法律状态:
    2021-04-09| FG| Patent granted|Effective date: 20210115 |
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    申请号 | 申请日 | 专利标题
    PCT/EP2019/051793|WO2020151829A1|2019-01-24|2019-01-24|Poultry feed and drinking water composition comprising a stable, bioavailable silicon complex|
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